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KMID : 1011620120280050569
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Korean Journal of Food and Cookey Science
2012 Volume.28 No. 5 p.569 ~ p.577
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Physicochemical Characteristics and Antioxidant activity, Antimutagenicity, and Cytotoxicity of Hot-water Extract of Hericium erinaceus
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김세령:Kim Se-Ryung
김미라:Kim Mee-Ra
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Abstract
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The physicochemical characteristics and biological activities, including antioxidant activity, antimutagenicity, and cytotoxicity of hot-water extract of fruiting body of Hericium erinaceus, were investigated in this study. Hot-water extract of fruiting body of Hericium erinaceus contained carbohydrate (7.86%), protein (10.91%), and β-glucan (3.62%). Water solubility of hot-water extract was 42.58%. Antioxidant activities of the extract were evaluated by ABTS assay and FRAP assay. The IC50 value was 312.21 ㎍/mL in ABTS assay. Antimutagenic activity of the extract was evaluated by Ames test. Antimutagenicity of hot-water extract (5 ㎎/mL) on Salmonella Typhimurium TA100 mutagenated by sodium azide (0.15 ㎍/㎎) was 69.2%. Cytotoxicity of hot-water extract was also evaluated by MTT and SRB assay. The cytotoxicity was highest (83.95%) on Hep3B treated with 2,000 ㎍/mL of hot-water extract in SRB assay. Therefore, it is suggested that hot-water extract of fruiting body of Hericium erinaceus has high antioxidant activity, antimutagenicity, and cytotoxicity.
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KEYWORD
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Hericium erinaceus, hot-water extract, antioxidant activity, antimutagenicity, cytotoxicity
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